- Title
- Genetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes
- Creator
- Vogelezang, Suzanne; Bradfield, Jonathan P.; Early Growth Genetics Consortium,; Grant, Sturan F. A.; Felix, Janine F.; Jaddoe, Vincent W. V.; Pennell, Craig E.; Wang, Carol
- Relation
- BMC Medical Genomics Vol. 15, no. 124
- Publisher Link
- http://dx.doi.org/10.1186/s12920-022-01281-1
- Publisher
- BioMed Central (BMC)
- Resource Type
- journal article
- Date
- 2022
- Description
- Background: Head circumference is associated with intelligence and tracks from childhood into adulthood. Methods: We performed a genome-wide association study meta-analysis and follow-up of head circumference in a total of 29,192 participants between 6 and 30 months of age. Results: Seven loci reached genome-wide significance in the combined discovery and replication analysis of which three loci near ARFGEF2, MYCL1, and TOP1, were novel. We observed positive genetic correlations for early-life head circumference with adult intracranial volume, years of schooling, childhood and adult intelligence, but not with adult psychiatric, neurological, or personality-related phenotypes. Conclusions: The results of this study indicate that the biological processes underlying early-life head circumference overlap largely with those of adult head circumference. The associations of early-life head circumference with cognitive outcomes across the life course are partly explained by genetics.
- Subject
- head circumference; genome-wide association study; genetic correlations; infancy
- Identifier
- http://hdl.handle.net/1959.13/1491761
- Identifier
- uon:53089
- Identifier
- ISSN:1755-8794
- Rights
- x
- Language
- eng
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